A recent review reveals that individuals undergoing specific antidepressant treatments may experience weight fluctuations in the initial two months, with potential gains of up to 2kg (4.5lbs) or losses of approximately 2.5kg (5.5lbs). Researchers aimed to assess the impact of various antidepressants on side effects within the first eight weeks of therapy.

The study, conducted by experts from the Institute of Psychiatry, Psychology & Neuroscience at King’s College London, analyzed data from over 150 studies involving 58,534 participants comparing 30 antidepressants with a placebo. Notable variations were observed in weight change, heart rate, and blood pressure. The findings, published in The Lancet, aim to empower patients to engage with healthcare providers regarding any concerns.

In the 2024/25 period, approximately 92.6 million antidepressant prescriptions were issued to an estimated 8.89 million patients in England. Sertraline, a commonly prescribed antidepressant, was administered to around 2.9 million patients, leading to an average weight loss of 0.76kg and a decrease in heart rate, yet it showed slight increases in blood pressure.

Amitriptyline, a tricyclic antidepressant given to 2.2 million patients, was associated with an average weight gain of 1.6kg, elevated heart rate, and increased blood pressure levels. While not recommended as a primary treatment, this drug is utilized for mood disorders and pain management.

Citalopram, another antidepressant, resulted in an average weight loss of 0.65kg, along with reductions in heart rate and systolic blood pressure, but a slight rise in diastolic blood pressure. The research highlighted significant variations in weight changes and heart rate among different antidepressants, emphasizing the importance of individualized care and informed decision-making between patients and healthcare professionals.

Experts stress the necessity for regular health monitoring during antidepressant treatment due to potential side effects on weight, heart rate, and blood pressure. They advocate for shared decision-making to tailor treatment plans to individual needs and preferences, promoting patient well-being.